The Big C on Netflix: Where to Watch, Cast, Plot - Netflix Tudum

  • Deep Dive

    The Big C: Laura Linney Seizes the Day in This Quirky Dark Comedy

    Getting diagnosed with terminal cancer inspires a woman to jumpstart her life in the series.

    By Ingrid Ostby
    Nov. 14, 2025

A Stage IV melanoma diagnosis sparks a new lease on life for Cathy (Laura Linney) in this 2010 series that ran for four seasons on Showtime. The dramedy, which also stars Oliver Platt, Gabriel Basso, and Gabourey Sidibe, follows Cathy, a married school teacher and mom, as she withholds her terminal prognosis from her loved ones. But when her newfound impulsivity gets her in hot water — burning a couch she hates, reigniting a steamy relationship with a painter — her family begins to wonder what’s really going on. How long until the jig is up? Created by Darlene Hunt (Call Me Kat, Dickinson), the full series is streaming on Netflix now. 

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Where can I watch The Big C?

Watch all four seasons on Netflix now

Laura Linney

Who’s in the cast of The Big C?

The cast of the first season includes:

  • Laura Linney (Ozark) as Cathy, a high school teacher
  • Oliver Platt (The Bear) as Paul, Cathy’s husband
  • Gabriel Basso (The Night Agent) as Adam, Cathy’s teenage son
  • John Benjamin Hickey (Lilly) as Sean, Cathy’s brother
  • Gabourey Sidibe (Empire) as Andrea, Cathy’s student
  • Reid Scott (Veep) as Dr. Mauer, Cathy’s oncologist
  • Phyllis Somerville (Our Souls at Night) as Marlene, Cathy’s neighbor
  • Cynthia Nixon (Sex and the City) as Rebecca, Cathy’s friend
  • Idris Elba (A HOUSE OF DYNAMITE) as Lenny, a painter at Cathy’s school
  • Brian Cox (Succession) as Donald Tolkey, Cathy’s father

Seasons 2 through 4 feature Hugh Dancy, Susan Sarandon, Alan Alda, Parker Posey, Brian Dennehy, Hamish Linklater, Kathy Najimy, Mamie Gummer, Isaac Mizrahi, Nadia Dajani, and more. 

Oliver Platt

What happens in The Big C?

Teacher Cathy Jamison (Linney) has her life turned upside down when she’s diagnosed with terminal melanoma. Instead of telling her loved ones, , Cathy decides to keep the news to herself. She starts living it up, doing things she never would’ve before. But her new way of life immediately has repercussions on her relationships — her son, Adam (Basso), and her brother, Sean (Hickey), are perplexed by her uncharacteristic behavior, and her marriage to Paul (Platt), quickly deteriorates after an incident with a school staff member, Lenny (Elba). Despite it all, her bond with her neighbor, Marlene (Somerville), and a new friendship with a student, Andrea (Sidibe), help Cathy navigate her new lease on life. But can she keep her illness hidden forever? 

Is The Big C based on a book?

No, the series isn’t based on a book. 

Laura Linney and a dog

Is The Big C based on a true story?

Nope, it’s fictional. 

Where does The Big C take place?

The series takes place in Minneapolis. 

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