But the actress truly seemed to hit her stride in her 30s, racking up an Emmy-winning guest stint as Jennifer Aniston's younger sister on "Friends" (2002-03); a Tony nod as the title character in "Sweet Charity" on Broadway; and a couple Emmy nominations for playing a recovering amnesiac on "Samantha Who?"
When it comes to big-screen comedy, Applegate has proved equally adept. She stepped as Cameron Diaz's best friend in The Sweetest Thing (2002) and also played the straight woman to an outrageous Will Ferrell in Anchorman: The Legend of Ron Burgundy (2004).
AddAnchorman: The Legend of Ron BurgundyWill Ferrell is hilarious as Ron Burgundy, a big-shot news anchor in 1970s San Diego whose reign over the newsroom is questioned when a hardworking feminist reporter, Veronica Corningstone (Christina Applegate), shows up and rocks the station with her new ideas. At first, Ron pretends he's hip to... Read More
AddThe Sweetest ThingTurnabout is fair play … especially when the "fairer sex" wears the pants. Club-hopping hottie Christina (Cameron Diaz) learns she must temper her voracious wooing approach when she sets her sights on baffled quarry Peter (Thomas Jane) and tracks him to his brother's wedding. Christina... Read More
AddDon't Tell Mom the Babysitter's DeadThrilled to have Mom out of their hair, four siblings are ready to celebrate when she departs for an extended tour of Australia -- until, that is, their elderly babysitter shows up. As luck would have it, though, the woman dies on her first night. Not to worry: The eldest of the pack (Christina... Read More
Add AllSamantha Who?: Season 1When Samantha Newly (Christina Applegate, in an Emmy-nominated role) awakens from a brief coma, she has no idea who she is. Struck with amnesia, she depends on those around her to fill in the blanks. But maybe she's better off in the dark: It seems Sam wasn't such a nice person before her accident.... Read More
AddPrince CharmingA prince (Sean Maguire) and his manservant (Martin Short) have lived a strange existence as frogs in Central Park after the prince's fiancée put a curse on him when she caught him cheating on her centuries earlier. Only a kiss will change them back into their former selves. But when they do... Read More
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